{"id":2241,"date":"2023-08-16T18:23:40","date_gmt":"2023-08-16T09:23:40","guid":{"rendered":"https:\/\/ocorearanews.com\/?p=2241"},"modified":"2023-08-16T18:23:40","modified_gmt":"2023-08-16T09:23:40","slug":"%ec%9c%a0%eb%b0%a9%ec%95%94-%ed%95%ad%ec%95%94%ec%a0%9c-%ec%9e%85%eb%9e%9c%ec%8a%a4-%ec%95%bd%eb%ac%bc-%eb%82%b4%ec%84%b1-%ed%95%9c%ea%b3%84-%eb%9b%b0%ec%96%b4%eb%84%98%ec%9d%84%ea%b9%8c","status":"publish","type":"post","link":"https:\/\/ocorearanews.com\/?p=2241","title":{"rendered":"\uc720\ubc29\uc554 \ud56d\uc554\uc81c &#8216;\uc785\ub79c\uc2a4&#8217;, \uc57d\ubb3c \ub0b4\uc131 &#8216;\ud55c\uacc4&#8217; \ub6f0\uc5b4\ub118\uc744\uae4c?"},"content":{"rendered":"<div id=\"newsct_article\" class=\"newsct_article _article_body\">\n<article id=\"dic_area\" class=\"go_trans _article_content\"><span class=\"end_photo_org\"><em class=\"img_desc\">\u00a0\uacf5\uaca9\uc801\uc778 \uc720\ud615\uc758 \uc7ac\ubc1c\u00b7\uc804\uc774\uc131 \uc720\ubc29\uc554 \ud658\uc790\uc758 \ud56d\uc554\uce58\ub8cc \uc0dd\uc874\uc728\uc774 \ub354\uc6b1 \ub192\uc544\uc9c8 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4. \ud314\ubcf4\uc2dc\ud074\ub9bd(\uc785\ub79c\uc2a4)\uc758 \uace0\uc9c8\uc801 \ubb38\uc81c\uc778 \uc57d\ubb3c \ub0b4\uc131 \ubc18\uc751\uc758 \uc8fc\uc694 \uc6d0\uc778\uc744 \uad6d\ub0b4 \uc5f0\uad6c\uc9c4\uc774 \ud655\uc778\ud588\uae30 \ub54c\ubb38\uc774\ub2e4. [\uc0ac\uc9c4=\uac8c\ud2f0\uc774\ubbf8\uc9c0\ubc45\ud06c]<\/em><\/span>\uacf5\uaca9\uc801\uc778 \uc720\ud615\uc758 \uc7ac\ubc1c\u00b7\uc804\uc774\uc131 \uc720\ubc29\uc554 \ud658\uc790\uc5d0 \ub300\ud55c \ud56d\uc554\uce58\ub8cc \uc0dd\uc874\uc728\uc774 \ub354\uc6b1 \ub192\uc544\uc9c8 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4. \uc8fc\uc694 \ud56d\uc554\uc81c\ub97c \uc0ac\uc6a9\ud560 \ub54c \uc77c\ubd80 \ud658\uc790\uc5d0\uac8c\uc11c \ub098\ud0c0\ub098\ub358 \uace0\uc9c8\uc801 \ubb38\uc81c\uc778 \uc57d\ubb3c \ub0b4\uc131 \ubc18\uc751\uc758 \uc8fc\uc694 \uc6d0\uc778\uc744 \uad6d\ub0b4 \uc5f0\uad6c\uc9c4\uc774 \ud655\uc778\ud588\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n<p>\uc0bc\uc131\uc11c\uc6b8\ubcd1\uc6d0 \ud608\uc561\uc885\uc591\ub0b4\uacfc \ubc15\uc5f0\ud76c \uad50\uc218\uc640 \uc0bc\uc131\uc720\uc804\uccb4\uc5f0\uad6c\uc18c \ubc15\uacbd\ud76c \uc5f0\uad6c\uc6d0, \uc11c\uc6b8\ub300\ubcd1\uc6d0 \ud608\uc561\uc885\uc591\ub0b4\uacfc \uc784\uc11d\uc544\u00b7\uc774\uacbd\ud6c8 \uad50\uc218, \ud654\uc774\uc790 \uc815\uc60c \uce78 \ubc15\uc0ac \uc5f0\uad6c\ud300\uc740 \uc720\uc804\uccb4 \ubd84\uc11d\uc744 \ud1b5\ud574 \ud45c\uc801\ud56d\uc554\uc81c &#8216;\ud314\ubcf4\uc2dc\ud074\ub9bd&#8217;\uc5d0 \ub0b4\uc131\uc744 \ubcf4\uc774\ub294 \ud658\uc790\uad70\uc758 \ud2b9\uc131\uc744 \uaddc\uba85\ud588\ub2e4.<\/p>\n<p>\ud314\ubcf4\uc2dc\ud074\ub9bd(\uc81c\ud488\uba85 \uc785\ub79c\uc2a4)\uc740 \ud638\ub974\ubaac \uc5b5\uc81c \uce58\ub8cc\uc81c\uc758 \uc77c\uc885\uc73c\ub85c, \uc554\uc758 \uc0dd\uc7a5\uc5d0 \uad00\uc5ec\ud558\ub294 &#8216;<span data-type=\"ore\" data-lang=\"en\">CDK4<\/span>&#8216;\uc640 &#8216;<span data-type=\"ore\" data-lang=\"en\">CDK6<\/span>&#8216;\ub77c\ub294 \ud6a8\uc18c\ub97c \uc5b5\uc81c\ud55c \ucd5c\ucd08\uc758 \uc57d\ubb3c\uc774\ub2e4. \uc7ac\ubc1c\uacfc \uc804\uc774\uac00 \ud65c\ubc1c\ud55c\u00a0<span data-type=\"ore\" data-lang=\"en\">HR<\/span>+\/<span data-type=\"ore\" data-lang=\"en\">HER2-<\/span>\u00a0\uc720\ubc29\uc554 \ud658\uc790\ub4e4\uc5d0 \ud65c\uc6a9\ub3fc \uce58\ub8cc \uc0dd\uc874\uc728\uc744 \ub04c\uc5b4\uc62c\ub838\ub2e4. \ub2e4\ub9cc, \uc57d\ubb3c \ub0b4\uc131 \ubb38\uc81c\ub294 \ub69c\ub837\ud55c \ud55c\uacc4\ub85c \uc9c0\uc801\ub3fc \uc654\ub2e4. \uac1c\ubc1c\uc0ac\uc778 \ud654\uc774\uc790\uac00 2016\ub144 \ucd9c\uc2dc\ud55c \ud6c4 \uad6d\uc81c \uc5f0\uad6c\ud300 \ud568\uaed8 \uc774\ub97c \uac1c\uc120\ud558\ub824 \uc2dc\ub3c4\ud588\uc9c0\ub9cc, 2018\ub144\uc5d0\ub3c4 \uc2e4\ud328\ud55c \ubc14 \uc788\ub2e4.<\/p>\n<p><span data-type=\"ore\" data-lang=\"en\">HR<\/span>+\/<span data-type=\"ore\" data-lang=\"en\">HER2-<\/span>\u00a0\uc720\ubc29\uc554\uc740 \uac01\uac01 &#8216;\uc5d0\uc2a4\ud2b8\ub85c\uac90 \ud638\ub974\ubaac \uc218\uc6a9\uccb4&#8217;\uc5d4 \uc591\uc131(\ud65c\uc131) \ubc18\uc751\uc744, &#8216;\uc0ac\ub78c \uc0c1\ud53c\uc138\ud3ec \uc131\uc7a5\uc778\uc790 \uc218\uc6a9\uccb42&#8217;\uc5d4 \uc74c\uc131\uc744 \ubcf4\uc778\ub2e4. \uad6d\ub0b4 \ud658\uc790\uc758 60%\uac00\ub7c9\uc744 \ucc28\uc9c0\ud560 \uc815\ub3c4\ub85c \uac00\uc7a5 \ud754\ud55c \uc720\ubc29\uc554 \uc885\ub958\ub85c, \ucd5c\uadfc\uc5d0\ub294 \uc644\uacbd\uae30 \uc774\uc804\uc758 \ube44\uad50\uc801 \uc80a\uc740 \ud658\uc790\uc5d0 \ub300\ud55c \ubc1c\ubcd1\ub960\ub3c4 \ud06c\uac8c \ub192\uc544\uc9c0\uace0 \uc788\ub2e4.<\/p>\n<p>\ub2e4\ub9cc, \ud22c\uc57d \ud658\uc790\uc758 4\uba85 \uc911 1\uba85\uaf34\ub85c \ud574\ub2f9 \uc57d\ubb3c\uc5d0 \ubc18\uc751\uc744 \ubcf4\uc774\uc9c0 \uc54a\uac70\ub098 \ub0b4\uc131\uc774 \uc788\uae30\ub3c4 \ud588\ub2e4. \uc774\uc5d0 \uc5f0\uad6c\uc9c4\uc740 \ub450 \ubcd1\uc6d0\uc5d0\uc11c 2017~2020\ub144 \uad00\ub828 \uce58\ub8cc\ub97c \ubc1b\uc740 \uc7ac\ubc1c\u00b7\uc804\uc774 \uc720\ubc29\uc554 \ud658\uc790 89\uba85\uc758 \uc885\uc591 \uc870\uc9c1\uc744\u00a0<span data-type=\"ore\" data-lang=\"en\">NGS<\/span>(\uc804\uc7a5 \uc720\uc804\uccb4 \ubd84\uc11d) \ubc29\uc2dd\uc73c\ub85c \uac80\uc0ac\ud588\ub2e4.<\/p>\n<p>\uc774\ub4e4 \ud658\uc790\uc758 \ud3c9\uade0 \uc5f0\ub839\uc740 45\uc138\uc600\uc73c\uba70 72%\uc5d0\uc11c \uc554\uc774 \uc9c4\ud589\ud588\ub2e4. \ubb34\uc9c4\ud589\uc0dd\uc874(<span data-type=\"ore\" data-lang=\"en\">PFS<\/span>) \uae30\uac04\uc740 \ud3c9\uade0 15\uac1c\uc6d4\uc774\uc5c8\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc720\uc804\uc790 \ubd84\uc11d \uacb0\uacfc\uc5d0\uc11c \uc57d\ubb3c\uc758 \ub0b4\uc131\uc744 \ubcf4\uc778 \ud658\uc790\uc758 \ubd84\uc790\uc801 \ud2b9\uc9d5\uc774 \uce58\ub8cc \uc804\ud6c4 \ub2ec\ub77c\uc9c4 \uac83\uc744 \ud655\uc778\ud588\ub2e4.<\/p>\n<p>\uc138\ud3ec \ub0b4\uc5d0\uc11c \uc190\uc0c1\ub41c\u00a0<span data-type=\"ore\" data-lang=\"en\">DNA<\/span>\uc758 \uc218\ub9ac \uae30\ub2a5\uc774 \uc81c\ub300\ub85c \uc791\ub3d9\ud558\uc9c0 \uc54a\ub294 \uc0c1\ud0dc\uc778 \u25b3\uc0c1\ub3d9 \uc7ac\uc870\ud569 \uacb0\ud54d(<span data-type=\"ore\" data-lang=\"en\">HRD<\/span>)\uc774 \uac00\uc7a5 \uc911\ub300\ud55c \uc694\uc778\uc774\uc5c8\ub2e4.\u00a0<span data-type=\"ore\" data-lang=\"en\">HRD<\/span>\ub294 \uc720\uc804\uc131 \uc720\ubc29\uc554\uc758 \uc6d0\uc778\uc778 \ub3cc\uc5f0\ubcc0\uc774 \uc720\uc804\uc790(<span data-type=\"ore\" data-lang=\"en\">BRCA1<\/span>\uacfc 2 \uc720\uc804\uc790)\uac00 \uc601\ud5a5\uc744 \uc8fc\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc84c\ub2e4.<\/p>\n<p>\ub3d9\uc2dc\uc5d0 \u25b3\uce58\ub8cc \uc804\ud6c4 \ubc1c\uc0dd\ud55c \uc885\uc591 \ub3cc\uc5f0\ubcc0\uc774(\uc5d0\uc2a4\ud2b8\ub85c\uac90 \ubc18\uc751\uc73c\ub85c \uc778\ud55c \uc720\uc804\uccb4 \ubc18\ud754<span data-type=\"ore\" data-lang=\"en\">\u00b7Genomic<\/span>\u00a0<span data-type=\"ore\" data-lang=\"en\">Scar<\/span>) \ub4f1\ub3c4 \uc57d\ubb3c \ub0b4\uc131\uacfc \ubcd1 \uc9c4\ud589\uc5d0 \uc601\ud5a5\uc744 \uc92c\ub2e4.<\/p>\n<p>\uc774\ub97c \ubc14\ud0d5\uc73c\ub85c \uc5f0\uad6c\uc9c4\uc740 \uc885\uc591 \uc99d\uc2dd \uc5b5\uc81c\uc5d0 \uad00\uc5ec\ud558\ub294\u00a0<span data-type=\"ore\" data-lang=\"en\">&#8216;TP53<\/span>\u00a0\uc720\uc804\uc790&#8217;\uc758 \ubcc0\uc774\uac00 \ub192\uc740 \uc218\uc900\uc758\u00a0<span data-type=\"ore\" data-lang=\"en\">HRD<\/span>\u00a0\uc0c1\ud0dc\uc640 \uacb9\uce58\uba74\uc11c \ud56d\uc554\uc81c\uc5d0 \ub300\ud55c \ub0b4\uc131\uc744 \ucd09\uc9c4\ud55c\ub2e4\uace0 \ud574\uc11d\ud588\ub2e4. \uc2e4\uc81c\ub85c\ub3c4 \ud574\ub2f9 \ud658\uc790\uad70\uc740 \ubcc0\uc774\uac00 \uc5c6\ub294 \ud658\uc790\uad70\ubcf4\ub2e4 \uc554\uc758 \uc9c4\ud589 \uc704\ud5d8\ub3c4\uac00 16.3\ubc30\ub098 \ub192\uc558\ub2e4. \uadf8\ub9cc\ud07c \ud56d\uc554\uce58\ub8cc \ud6c4 \uc720\ubc29\uc554\uc758 \uc7ac\ubc1c \ud639\uc740 \uc804\uc774\uac00 \ube60\ub974\uac8c \uc77c\uc5b4\ub09c \uac83\uc774\ub2e4.<\/p>\n<p>\uc5f0\uad6c\ud300\uc740 &#8220;\uc774\uc804\uc5d0\ub294\u00a0<span data-type=\"ore\" data-lang=\"en\">CDK4<\/span>\/6 \uc5b5\uc81c\uc81c \uc0ac\uc6a9\uc774 \ud544\uc694\ud55c \uc804\uc774\uc131 \uc720\ubc29\uc554 \ud658\uc790 \uc911 \ub0b4\uc131\uc744 \uadf9\ubcf5\ud560 \uc218 \uc788\ub294 \ud658\uc790\ub97c \uad6c\ubd84\ud558\uae30 \uc704\ud55c \uc9c0\ud45c\uac00 \uc5c6\ub294 \uc0c1\ud669\uc774\uc5c8\ub2e4&#8221;\uba74\uc11c &#8220;\uc804\uc774\uc131 \uc720\ubc29\uc554 \ud658\uc790\ub4e4\uc774 \uc2dc\ub984\uc744 \ub35c \uc218 \uc788\ub3c4\ub85d \ud6c4\uc18d \uc5f0\uad6c\uc5d0\uc11c \uc774\ub97c \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uce58\ub8cc \uc804\ub7b5\uc744 \ub0b4\ub193\uaca0\ub2e4&#8221;\uace0 \ub9d0\ud588\ub2e4.<\/p>\n<p>\uc774\ubc88 \uc5f0\uad6c\ub294\u00a0<span data-type=\"ore\" data-lang=\"en\">HR<\/span>+\/<span data-type=\"ore\" data-lang=\"en\">HER2-<\/span>\u00a0\uc804\uc774\uc131 \uc720\ubc29\uc554\uc5d0\uc11c\u00a0<span data-type=\"ore\" data-lang=\"en\">HRD<\/span>\uac00 \ub0b4\uc131 \uc6d0\uc778\uc784\uc744 \ubc1d\ud78c \ucd5c\ucd08\uc758 \uc804\ud5a5\uc801 \uc5f0\uad6c\ub85c \uad6d\uc81c \ud559\uc220\uc9c0 &#8216;\uac8c\ub188 \uba54\ub514\uc2e0&#8217; \ucd5c\uadfc\ud638\uc5d0 \ubc1c\ud45c\ud588\ub2e4. \ucd5c\uc885 \ubc1c\ud45c\uc5d0 \uc55e\uc11c 2020\ub144 \uc0cc\uc548\ud1a0\ub2c8\uc624\uc720\ubc29\uc554\uc2ec\ud3ec\uc9c0\uc5c4\uacfc 2021\ub144 \ubbf8\uad6d\uc784\uc0c1\uc885\uc591\ud559\ud68c(<span data-type=\"ore\" data-lang=\"en\">ASCO<\/span>)\uc5d0\uc11c\ub3c4 \ud3ec\uc2a4\ud130 \ubc1c\ud45c\ub85c \uc77c\ubd80 \ub0b4\uc6a9\uc774 \uacf5\uac1c\ub3fc \ud559\uacc4\uc758 \uc8fc\ubaa9\uc744 \ubc1b\uae30\ub3c4 \ud588\ub2e4.<\/p>\n<div class=\"nbd_im_w _LAZY_LOADING_WRAP \">\n<div id=\"img_a2\" class=\"nbd_a _LAZY_LOADING_ERROR_HIDE\"><img decoding=\"async\" id=\"img2\" class=\"_LAZY_LOADING\" src=\"https:\/\/imgnews.pstatic.net\/image\/296\/2023\/08\/16\/0000068774_002_20230816170001415.jpg?type=w647\" \/><\/div>\n<\/div>\n<p><span class=\"end_photo_org\"><em class=\"img_desc\"><span data-type=\"ore\" data-lang=\"en\">CDK4<\/span>\/6 \uc5b5\uc81c \ubc29\uc2dd\uc758 \uc720\ubc29\uc554 \ud56d\uc554\uc81c\uc778 \uc785\ub79c\uc2a4(\ud314\ubcf4\uc2dc\ud074\ub9bd) \uc81c\ud488 \ubaa8\uc2b5. [\uc0ac\uc9c4=\ud654\uc774\uc790]<\/em><\/span><\/p>\n<\/article>\n<\/div>\n<div class=\"byline\">\n<p class=\"byline_p\"><span class=\"byline_s\">\ucd5c\uc9c0\ud604 jh@kormedi.com<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0\uacf5\uaca9\uc801\uc778 \uc720\ud615\uc758 \uc7ac\ubc1c\u00b7\uc804\uc774\uc131 \uc720\ubc29\uc554 \ud658\uc790\uc758 \ud56d\uc554\uce58\ub8cc \uc0dd\uc874\uc728\uc774 \ub354\uc6b1 \ub192\uc544\uc9c8 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4. \ud314\ubcf4\uc2dc\ud074\ub9bd(\uc785\ub79c\uc2a4)\uc758 \uace0\uc9c8\uc801 \ubb38\uc81c\uc778 \uc57d\ubb3c \ub0b4\uc131 \ubc18\uc751\uc758 \uc8fc\uc694 \uc6d0\uc778\uc744 \uad6d\ub0b4 \uc5f0\uad6c\uc9c4\uc774 \ud655\uc778\ud588\uae30 \ub54c\ubb38\uc774\ub2e4. [\uc0ac\uc9c4=\uac8c\ud2f0\uc774\ubbf8\uc9c0\ubc45\ud06c]\uacf5\uaca9\uc801\uc778 \uc720\ud615\uc758 \uc7ac\ubc1c\u00b7\uc804\uc774\uc131 \uc720\ubc29\uc554 \ud658\uc790\uc5d0 \ub300\ud55c \ud56d\uc554\uce58\ub8cc \uc0dd\uc874\uc728\uc774 \ub354\uc6b1 \ub192\uc544\uc9c8 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4. \uc8fc\uc694 \ud56d\uc554\uc81c\ub97c \uc0ac\uc6a9\ud560 \ub54c \uc77c\ubd80 \ud658\uc790\uc5d0\uac8c\uc11c \ub098\ud0c0\ub098\ub358 \uace0\uc9c8\uc801 \ubb38\uc81c\uc778 \uc57d\ubb3c \ub0b4\uc131 \ubc18\uc751\uc758 \uc8fc\uc694 \uc6d0\uc778\uc744 \uad6d\ub0b4 \uc5f0\uad6c\uc9c4\uc774 \ud655\uc778\ud588\uae30 \ub54c\ubb38\uc774\ub2e4. \uc0bc\uc131\uc11c\uc6b8\ubcd1\uc6d0 \ud608\uc561\uc885\uc591\ub0b4\uacfc [&hellip;]<\/p>\n","protected":false},"author":241,"featured_media":2242,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,47],"tags":[],"class_list":["post-2241","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","category-47"],"_links":{"self":[{"href":"https:\/\/ocorearanews.com\/index.php?rest_route=\/wp\/v2\/posts\/2241","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ocorearanews.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ocorearanews.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ocorearanews.com\/index.php?rest_route=\/wp\/v2\/users\/241"}],"replies":[{"embeddable":true,"href":"https:\/\/ocorearanews.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2241"}],"version-history":[{"count":1,"href":"https:\/\/ocorearanews.com\/index.php?rest_route=\/wp\/v2\/posts\/2241\/revisions"}],"predecessor-version":[{"id":2243,"href":"https:\/\/ocorearanews.com\/index.php?rest_route=\/wp\/v2\/posts\/2241\/revisions\/2243"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ocorearanews.com\/index.php?rest_route=\/wp\/v2\/media\/2242"}],"wp:attachment":[{"href":"https:\/\/ocorearanews.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ocorearanews.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ocorearanews.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}